Spark plug life has been an issue with my Jota since I first bought the bike. It had Dellortos and a DMC 1 when I bought it. Some years later the DMC got replaced with an Ignitech. Then another couple of years later, the carbs got replaced with Mikunis. The bike has been dyno tuned several times to make sure carburettor and ignition settings are OK. But the plug issues remained through all the upgrades and tuning.
I suppose the root cause could be mechanical, such as sucking a bit of oil into the cylinders. The engine has done around 100,000 km. It runs well and doesn't blow any visible smoke. But maybe the rings and valve guides are past their prime.
Interestingly, when I pull a misfiring plug, there's no obvious fouling on it. The colour always looks OK and it's the same as the plug in the next cylinder that's working OK. In fact, I can't tell which cylinder is misfiring just by looking at the plugs. But replacing it with a new plug always clears the misfire. Occasionally, when I haven't had a new plug to hand, I've restored a misfiring plug to working condition by heating it with a propane torch to burn off any residue that might be on it. But the burn-off fix doesn't tend to last very long. A couple of tankfuls of fuel later and it starts to misfire again. Can get a bit tedious on a long trip.