From my perspective, the main problem is the use of inferior quality chain just because it is the same size. Also, if using a split link, using incompatible ones, or ones which have been clipped already. The spring clip is a single use item in an ideal world. I won't use a split link (on a camchain) unless it's still in the plastic bag with the part number on it, so I know it is correct for the given chain and the clip is unused.
I did run clip link single row primary chains on road bikes for a while back when I couldn't easily source the correct ones, I used Regina C121HCS chain and links and touch wood never had an issue.
These days with the Iwis G76HP endless chains so high quality and fairly easy to get, it's a no brainer. Either two single row ones on a 120 or a duplex on anything earlier.
I broke a triplex primary chain in my 750 racebike after purchasing it from Chris, it was a clip link chain but it broke away from that link. It was a shit quality chain. At Phillip Island back in 08 I arrived with hope of using the belt drive which failed in short order so I had to source some Tsubaki industrial triplex chain from Melbourne (thanks Ian!) and robbed the sprockets from the genuine SFC on the day. I put a new chain in each day just to be on the safe side and it worked. Later when running the bike more regularly the Iwis G67HP duplex had become available and I used that without incident, initially still changing it daily, eventually comfortable to leave it in for the duration of a three day meeting. There was never any perceptible wear or signs of trouble, they would probably last much longer but a new chain is cheap insurance in the context of a multi-thousand dollar weekend even if things go smoothly.