So I guess the big difference to older type longitudinal arranged bikes like a guzzi or old BM is that the V6 clutch is wet. Interesting hearing Honda's solutions, I knew the CX had the clutch at the front and gearbox under, but it never clicked that the gold wing did too. But that puts the engine weight up high, manageable on the CX or the gold wing flat four but worse if you'd try it with a V6.
Marnix' tale of working on the V6 reminds me of Gerry Burgess' culture shock when going from the easy to work on Yamaha to the early desmosedici with the frameless design when Rossi did his disasterous switch in 11/12. You have to split the whole bike to do certain tasks. Even Christiane's small block guzzi was similar.. very hard to access the gearbox, given (like the V6) the swingarm pivoted off it. Had to lift the entire top of the bike off it and wheel it away like a wheelbarrow, then split and remove the engine, then support the lower frame rails and remove the swingarm and rear wheel, only then can you get the gearbox out, by which time the only thing holding the remains of the bike from falling into a pile on the bench is the centrestand! Actually fairly quick and easy when you get your head around it but it was certainly odd.
Re 60 vs 90 vees, I can only assume the 60 degree often used by V6 and V12 engines was done for packaging and/or just to have an even fire arrangement which made spark easier in the early days and makes the tone more agreeable. The Lav V6 sounds great but it's small and revvy, and most engines like that sound good to some degree. I know the old V6 Holdens of the 90's which used the buick 90deg V6 sound absolutely terrible. Don't know about the Maserati/citroen ones. I've seen an SM a few times in canberra with that engine, but it's silent.
The advantage of 90deg is secondary balance, which is perfect whereas 60deg is really bad. All you have with a 90deg V6 is a bit of primary rocking couple from the 120 crank, and in the case of the V6 with it being longitudinal and with small/light rotating parts and long/heavy overall bike, it is presumably negligible.